Born on 1st June, 1972 in a small village named Hanol located in Palitana taluka, District Bhavnagar of Gujarat state in a middle-class farmer’s family.

In 1992, at the age of 20 years, he became a member of Akhil Bharatiya Vidhyarthi Parishad and by his organizational skills, he soon became a State Executive Member of Akhil Bharatiya Vidhyarthi Parishad.

1996 was the year when Shri Mansukh Mandaviya joined politics after becoming a member of Bharatiya Janata Yuva Morcha (BJYM) and played a key role in various activities.

In 1998, Mansukh Mandaviya became President of Palitana Taluka BJP.

When he was elected, he was the youngest MLA in Gujarat Legislative Assembly.

As a Member of Legislative Assembly he undertook a 123 KM long Padyatra, titled "Kanya Kelavani Jyot Padyatra" for the Social Cause 'Beti Bachao-Beti Padhao' for 45 educational backward villages of his constituency. Due to this initiative school enrollment ratio of Palitana for girls reached 1007 and drop-out ratio could be lower than State average for girls.

Shri Mansukh Mandaviya became Chairman, Gujarat Agro Industries Corporation Ltd. As a Chairman he took innovative measures like E-Radiation treatment plant at Bavla, which is First Government Facility; Poha (Flattened Rice) plant at Navsari; Modern banana Pack house at Achaliya (Bharuch) and Bio-Fertilizers Plant at Gondal.

Considering his organizational skills, he was appointed as General Secretary in BJP. He is youngest State General Secretary of BJP Organization.

On Completion of First successful term as a Member of Rajya Sabha, he was re-elected for Upper House for the period 2018-2024

India achieved a historic milestone by crossing 200 crore COVID-19 vaccine doses on 17 July 2022. Accomplished in just 18 months, this feat reflects the scale, speed, and inclusivity of the world’s largest vaccination drive.

Marked a significant milestone in India’s healthcare innovation by unveiling the world’s first intranasal COVID-19 vaccine, iNNCOVACC, on 26 January 2023. This needle-free vaccine highlights India’s growing leadership in vaccine research and development and stands as a strong step towards Atmanirbhar Bharat, making vaccination more accessible, affordable, and future-ready.

Reinforced India's global vision for healthcare innovation at the World Economic Forum, Davos, on 18 January 2023. The discussion highlighted the country’s commitment to strengthening R&D, fostering innovation in the Pharma-MedTech sector, and building a globally competitive life sciences ecosystem focused on accessibility, affordability, and cutting-edge technology.

Delivered the keynote address at the concluding session of the G20 Health Working Group Meeting on 18 April 2023, highlighting the need for collective global action on pandemic preparedness, prevention, and response.

Launched the NaMo Free Dialysis Centre, 100th Jan Aushadhi Kendra, NaMo Day Care Center, and NaMo Mobile Healthcare Units in Bengaluru on 5th Jan Aushadhi Diwas to strengthen affordable and accessible healthcare services.

Assumed charge as Union Minister for Youth Affairs & Sports and Minister of Labour & Employment in the Modi 3.0 government.

Launched Sundays on Cycle, a nationwide initiative to promote fitness, cycling, and eco-friendly mobility while encouraging mass participation in the Fit India Movement for building a healthier and developed nation.

Delivered India’s National Statement at the 113th International Labour Conference in Geneva, highlighting India’s progress in job creation, social protection, digital labour platforms, and inclusive workforce development.

Introduced as the biggest sports reform since Independence, the National Sports Governance Act, 2025 was passed by Parliament to revamp sports administration and strengthen transparency, accountability, and athlete-centric governance.

Conferred with the prestigious ISSA Award 2025 for expanding social security coverage from 19% in 2015 to 64.3% in 2025, reaching over 940 million citizens through transformative welfare and digital inclusion initiatives.

Announced Ahmedabad’s hosting rights for the 2030 Commonwealth Games, marking a major milestone in India’s journey towards becoming a global sporting nation while boosting sports infrastructure, tourism, and international sporting events.

Led the Indian delegation at the Second World Summit for Social Development (WSSD-2) in Doha, Qatar, highlighting India’s achievements in poverty reduction, social security expansion, and inclusive social development.

Led the 180-km Sardar@150 Unity March from Karamsad to the Statue of Unity to commemorate Sardar Vallabhbhai Patel’s 150th birth anniversary and celebrate his legacy of national unity, integration, and strong governance.